These are gastro retentive drug delivery dosage systems grdds based on noneffervescent approach. It can be used for imaging liver metastases and also can be used to distinguish bowel loops from other abdominal structures by forming nano size particles supramagnetic iron oxides. The collected microspheres were dried in desiccators. The present study was designed to investigate the effects of different variables on the release profile of ibuprofen microspheres formulated using modified emulsification method. The concept of targeted drug delivery is designed for attempting to concentrate the drug in the tissues of interest while reducing the relative concentration of the medication in the remaining tissues. Pdf the main aim of the present investigation is to formulate omeprazole loaded floating microspheres by solvent evaporation technique. The pre pared microspheres were evaluated for size, in vitro. Floating microspheres were prepared by solvent evaporation oilinwater emulsion technique using. Formulation, optimization and evaluation of floating. Role of excipients and polymeric advancements in preparation of. Preparation and invitro evaluation of floating microspheres of gabapentin article pdf available january 2011 with 180 reads how we measure reads. Preparation and evaluation of floating microspheres of. Pdf formulation of floating microspheres of nizatidine. A well designed controlled drug delivery system can overcome some of the problems of conventional therapy and enhance the therapeutic efficacy of a given drug.
The microspheres were prepared by oilinoil emulsion solvent evaporation technique using ethyl cellulose, methacrylic acid copolymer eudragit rs100, eudragit rspo and eudragit rlpo. Sodium alginate alone or in combination with guargum and the gas forming agent sodium carbonate were dispersed in the purified water to form a homogeneous polymer mixture. The amount of sodium alginate, amount of calcium chloride, and amount of. Preparation of microsphere floating microsphere containing metformin hydrochloride was prepared using emulsion solvent diffusion technique19. Microspheres was spread over a surface of a usp xxii dissolution apparatus type ii filled with 900ml 0.
Pdf the present study involves prepration and evaluation of floating microspheres using boswellic ba as model drug for prolongation of the. Floating microspheres are prepared by solvent diffusion and evaporation methods to create the hollow inner core. Weight of floating micr ospheres percentage yield x 100. The floating microspheres were taken for micromeritic properties such as bulk density, tapped density, carrs index, hausners ratio, angle of repose. References powders and granulates freeflowing powders and granulates are needed for a variety of industrial processes. The microspheres were analyzed for drug entrapment, bulk density, angle of repose, particle size and invitro release pattern. Hollow microsphere promises to be a potential approach for gastric retention. During the preparation of microspheres or after the formation of microspheres by incubating. Formulation and evaluation of captropril microspheres by. Preparation of omeprazole floating microspheres the floating micro spheres were prepared by solvent evaporation method.
As a result, drug is localized on the targeted site. Pdf preparation and invitro evaluation of floating. In this the prepared loaded microsphere is analyzed by scanning electronic microscopesemafter palladiumgold coating of the samples on an aluminium strip. Ofloxacin 500 mg and polymer 500 mg were weighed accurately. The objective of the present investigation is to formulate multiparticulate gastroretentive dosage form of nizatidine, a h2receptor antagonist widely prescribed in gastric ulcers, duodenal ulcers. Application and advancement of microsphere as controlled. Formulation development and evaluation of alginate. The effect of various formulation variables on the size and drug release was investigated. Floating microspheres are, in a strict sense, spherical empty particles without a core.
Floating microspheres are gastroretentive drug delivery systems based on a noneffervescent approach. Formulation, optimization and evaluation of floating microspheres of captopril. The polymer content was a mixture of eudragit rs 100 hydroxypropylmethylcellulose hpmc k4m. The main aim of the present investigation is to formulate omeprazole loaded floating microspheres by solvent evaporation technique. Preparation and characterization of gastroretentive. Of pharmaceutics, jaipur college of pharmacy, sitapura, jaipur raj. A controlledrelease system designed to increase residence time in the stomach without contact with the mucosa was achieved through the preparation of floatingmicrospheres by. Hollow microspheres, microballoons or floating microparticles are terms used synonymously for floating microspheres.
The prepared microspheres were collected and weighed from different formulations. Recent trends in the development of gastroretentive floating drug delivery system p. Gastro retentive floating microspheres are low density systems that have sufficient buoyancy to float over the gastric contents and remain in stomach for prolonged period and slowly released the drug at desired rate. Formulation and invitro evaluation of mucoadhesive. Preparation of floating microspheres the floating microspheres were prepared by solvent evaporation method. Preparation of ritonavir floating microspheres 5 the floating microspheres containing ritonavir were prepared by orifice ionic gelation technique. Effect of various polymers concentrations on physicochemical. Preparation of eudragit e100 microspheres by modified solvent evaporation method vandana singh 1 and amrendra kumar chaudhary2 1translam institute of pharm education and research, meerut, up250001, india 2school of pharmaceutical sciences, shobhit university, meerut, up250110, india. They are spherical free flowing particles consisting of proteins or synthetic polymers which are biodegradable in nature. Floating microspheres provide a constant and prolonged therapeutic effect which will reduce dosing frequency. Preparation and in vitro characterization of porous carrierbased. Pdf formulation and evaluation of floating microspheres of.
The drug to polymer ratio was used to prepare the different formulation. Preparation of floating microspheres of dextromethorphan hbr floating microsphere of dxm hbr was prepared by emulsion solvent evaporation technique. The dried floating microspheres were evaluated for percentage yield %, actul drug content %. Microspheres are multiparticulate drug delivery systems which are prepared to obtain prolonged or controlled drug delivery to improve bioavailability, stability and to target the drug to specific site at a predetermined rate. Pdf formulation and evaluation of metformin hcl floating. The particle size of the microspheres was measured using an optical microscope and the mean particle size was calculated by measuring 100 particles with. Drug and required polymer, excipients were taken in different ratios as shown in table 1. Microspheres microspheres are small spherical particles, with diameter 1. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Preparation of floating microspheres floating microspheres were prepared by ionotropic gelation method. To this dispersion, desired polymer in different concentrations was mixed in suitable proportion and stirring is continued. Preparation of microsphere the microspheres were prepared using an ionic.
Preparation of polylactidecoglycolide microspheres and. The aim of present study involves preparation and characterization of floating microspheres using trimetazidin dihydrochloride as a model drug to increase the residence time in the stomach without contact with the mucosa, floating microspheres were prepared by the capillary extrusion technique using chitosan as polymer and sodium. The recent developments of fdds including approaches to design singleunit and multipleunit floating systems, mechanism of floating microspheres, methods of preparation of hollow microsphere, list of polymers used in hollow microspheres, characterization of hollow. Contents of the powerpoint on formulation and evaluation of microspheres include. Preparation and characterization of floating drug delivery system of azithromycin shailendra wasnik, poonam parmar, deepika singh and alpana ram. Total ten formulations were prepared by altering the concentration of drug to polymer concentrations. The mgalldh shell was obtained on the surface of fe 3o. The floating microspheres were prepared by emulsion solvent diffusion technique1. Formulation and evaluation of gastroretentive drug delivery system. Drug and excipients were dissolved in ethanol and dichloromethane 1. In the present study microspheres containing felodipines were prepared by solvent evaporation method and characterized by optical microscopy and scanning electron microscopy. The drug is released slowly at the desired rate, and the system is found to be floating on gastric content and increases gastric.
Pdf formulation and evaluation of floating microsphere. Eight batches of microspheres f1f8 were prepared by applying 2 3 factorial design. The resulting microspheres were washed with double distilled. Formulation and evaluation of captropril microspheres by ionic gelation technique s. The layer of buoyant microspheres was pipetted and separated by filtration at 1, 2, 4 and 6 hours. Different quantities of ethyl cellulose and eudragit s 100 were dissolved in dichloromethane by magnetic stirrer. This organic phase was added slowly to 100 ml of 1. Preparation and in vitro characterization of porous.
The effect of various formulation variables on the. The oo single emulsionsolvent evaporation is the best method used for preparation of floating microspheres of gabapentin using ethyl cellulose and cellulose acetate as coating polymeric. Chitosanbased floating microspheres of trimetazidin. The floating and the settled portion of microsphere will be recovered separately. Formulation and evaluation of controlled release floating. The purpose of this study is to formulation and invitro evaluation of mucoadhesive floating microspheres of repaglinide using solvent evaporation method.
Research paper preparation and characterization of serratiopeptidase containing microspheres j. Application and advancement of microsphere as controlled delivery system. Of microspheres theoretical wgt to be preparedloading 100 x actual amt. Floating microspheres have been utilized to obtain prolonged and uniform release of drug in the stomach for development of oncedaily formulations. Research paper preparation and characterization of.
Formulation and evaluation of gastroretentive floating. Floating microspheres19, 20 in floating types the bulk density is less than the gastric fluid and so remains buoyant in stomach without. The measured weight was divided by the total amount of drug and polymers which were used for the preparation of the microspheres to obtained percentage yield. Optimization of methods for the preparation of famotidine.
These systems have several advantages over conventional multi dose therapy. General method for preparation of floating microspheres floating microspheres containing ofloxacin hydrochloride were prepared by an emulsification solvent evaporation technique soppimath et al. Accurately weighed amount of drug was dispersed uniformly in aqueous mucilage of sodium alginate with stirring. Floating microspheres of tolperisone hydrochloride. All the five formulation displayed sustained release of drug. Optimization of methods for the preparation of famotidine floating microspheres singh bandana, kanoujia jovita, pandey manisha, koshy m. Floating behavior of floating microsphere12,37 100 mg of the floating microsphere were placed in 0.
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